Herb in Thai notifiable formulas
Siamese Neem
สะเดา · Sadao
Azadirachta indica A. Juss. var. siamensis Valeton
- Family
- Meliaceae
- Part used
- root
- Crude drug
- Azadirachtae Siamensis Folium
- Other names
- Siamese Nim Leaf
- In the announcement
- Used in 3 notifiable formulas (1 as capsules)
Thai Herbal Pharmacopoeia (THP)
Constituents and quality criteria of Siamese Neem
Summarised from the Siamese Neem Leaf monograph of the Thai Herbal Pharmacopoeia, Department of Medical Sciences, the standard used to test the dried leaflets.
The pharmacopoeia sets no minimum marker content for this herb. Use the raw material quality criteria below for acceptance testing.
Constituents
Siamese Neem Leaf contains tetranortriterpenoids (e.g., azadirachtin) and flavonoids (e.g., quercetin and rutin). Description of plant (Fig. 1) Evergreen tree, up to 20 m tall; bark greyish brown, vertically striated. Leaves pinnately compound, spirally arranged, young leaves usually reddish; exstipulate; rachis 20 to 40 cm long; petiole 6 to 14 cm long, slender, swollen at base; leaflets 6 to 12 pairs, opposite or subopposite, leaflet at tip sometimes reduced; exstipellate; petiolule 4 to 7 mm long, slender, glabrous; lamina oblanceolate or broadly falcate, 6.5 to 12.5 cm long, 2.1 to 5.2 cm wide, apex acuminate, base oblique, margin serrate or serrate-undulate, coriaceous, glabrous, lateral nerves 8 to 13 pairs, slender, prominent, veinlets reticulate, fainted. Inflorescence panicle, axillary or terminal, up to 30 cm long, appearing before leaves. Flower white, bisexual, 1 to 1.5 cm in.
The THP monograph covers the leaf, while the formulas use the root, so the quality criteria on this page apply to the leaf only.
Raw material quality criteria
| Foreign matter | Not more than 2.0% w/w |
| Loss on drying | Not more than 11.0% w/w |
| Total ash | Not more than 12.0% w/w |
| Acid-insoluble ash | Not more than 1.0% w/w |
| Water-soluble extractive | Not less than 20.0% w/w |
| Ethanol-soluble extractive | Not less than 5.0% w/w |
Storage: Siamese Neem Leaf shall be kept in well-closed containers, protected from light, and stored in a dry place.
Source: Thai Herbal Pharmacopoeia, Department of Medical Sciences (online edition, accessed 21 October 2026)Read the full THP monograph
Formulas using Siamese Neem
3 formulas containing Siamese Neem
Select a formula to see its ingredients and indications. Formula names and indications are a reference translation; the Thai announcement is the legal text.
- Ya Kae Khai Phuea Samha Formula for phlegm-type feverRelieves fever due to phlegm (khai phuea samha) (fever with alternating hot flushes and chills, having a cold)
- Ya Kae Khai Phuea Samha Formula for phlegm-type feverRelieves fever due to phlegm (khai phuea samha) (fever with alternating hot flushes and chills, having a cold)
- Ya Kae Khai Phuea Samha Formula for phlegm-type feverRelieves fever due to phlegm (khai phuea samha) (fever with alternating hot flushes and chills, having a cold)
Development potential
Develop Siamese Neem into a product with the TIBD group
In notifiable formulas3 formulasused in multi-herb formulas
THP raw-material criteria6 testsfor acceptance testing before production
Marker with a minimum contentNot setquality is checked with the raw-material criteria
Three ways forward 1Notify a listed formula2Adapt it through detailed notification3Develop a Category B herbal medicine or Category C health productSee the development pathway
K-API · manufacturing in the group
Extract and manufacture at K-API
The TIBD group plant licensed by the Thai FDA to manufacture herbal products, so extraction and production stay within the group.
See the K-API plantTIBD · consultationPlan a product with Siamese Neem
We check whether your formula qualifies for notification, detailed notification or registration with the Thai FDA, then prepare the filing documents.
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