Herb in Thai notifiable formulas
Lime Peel
มะนาว · Manao
Citrus × aurantiifolia (Christm.) Swingle
- Family
- Rutaceae
- Part used
- fruit
- Crude drug
- Citri Aurantiifoliae Exocarpium et Mesocarpium
- Other names
- Common Lime Peel, Sour Lime Peel
- In the announcement
- Used in 11 notifiable formulas (3 as capsules)
Thai Herbal Pharmacopoeia (THP)
Constituents and quality criteria of Lime Peel
Summarised from the Lime Peel monograph of the Thai Herbal Pharmacopoeia, Department of Medical Sciences, the standard used to test the dried exocarp with unremovable mesocarp.
The pharmacopoeia sets no minimum marker content for this herb. Use the raw material quality criteria below for acceptance testing.
Constituents
Lime Peel contains volatile oils consisting of limonene, β-pinene, and α-terpineol. It also contains limonoids and flavonoids, i.e., hesperidin. Other compounds are coumarins, phenolic acids, carotenoids, etc.
The THP monograph covers the fruit peel, while the formulas use the root, leaf, fruit and pickled fruit, so the quality criteria on this page apply to the fruit peel only.
Raw material quality criteria
| Foreign matter | Not more than 2.0% w/w |
| Total ash | Not more than 10.0% w/w |
| Water-soluble extractive | Not less than 19.0% w/w |
| Ethanol-soluble extractive | Not less than 6.0% w/w |
| Volatile oil | Not less than 2.0% v/w |
Storage: Lime Peel shall be kept in well-closed containers, preferably of metal or glass, protected from light, and stored in a dry place. Identication 0.5A. To 500 mg of the sample, in powder, add 15 mL of ethanol, shake, allow to stand for 30 minutes, and filter (solution 1). To 2 mL of solution 1, add 2.
Source: Thai Herbal Pharmacopoeia, Department of Medical Sciences (online edition, accessed 21 October 2026)Read the full THP monograph
Formulas using Lime Peel
11 formulas containing Lime Peel
Select a formula to see its ingredients and indications. Formula names and indications are a reference translation; the Thai announcement is the legal text.
- Sitrat Bai-o Flewanoi Citrus bioflavonoidsA source of antioxidants
- Ya Prasa Chan Daeng Red sandalwood formula for fever and thirstRelieves fever (khai tua ron) (toxic fever, khai phit), relieves internal heat (ron nai) and thirst
- Ya Lueat Ngam Women's blood formula for menstrual painRelieves menstrual pain, helps menstruation come normally, relieves mutakit (abnormal vaginal discharge)
- Ya Prasa Chan Daeng Red sandalwood formula for fever and thirstRelieves fever (khai tua ron) (toxic fever, khai phit), relieves internal heat (ron nai) and thirst
- Ya Prasa Chan Daeng Red sandalwood formula for fever and thirstRelieves fever (khai tua ron) (toxic fever, khai phit), relieves internal heat (ron nai) and thirst
- Ya Hom Thep Chit Fragrant cordial formula for dizziness and palpitationsRelieves subtle wind (lom kong la-iat) causing symptoms such as dizziness, faintness (sawing sawai), palpitations, etc., and nourishes the mind (bamrung duang chit) so that it is refreshed
- Ya Lueat Ngam Women's blood formula for menstrual painRelieves menstrual pain, helps menstruation come normally, relieves mutakit (abnormal vaginal discharge)
- Ya Kae Ai Phasom Kanphlu Cough formula with cloveRelieves cough, expels phlegm and soothes the throat
- Ya Kae Ai Phasom Manao Dong Cough formula with pickled limeRelieves cough, expels phlegm and soothes the throat
- Ya Kae Lom Amphruek Amphat Traditional formula for lom amphruek amphatRelieves paresis and paralysis wind (lom ammaphruek ammaphat)
- Tamrap Samunphrai Bamrung Rang Kai Formula 6 Herbal body tonic, Formula 6Nourishes the body (body tonic)
Development potential
Develop Lime Peel into a product with the TIBD group
In notifiable formulas11 formulas1 as a single-herb formula
THP raw-material criteria5 testsfor acceptance testing before production
Marker with a minimum contentNot setquality is checked with the raw-material criteria
Testing in the groupVISBIOVolatile compound analysis by GC-MS
Three ways forward 1Notify a listed formula2Adapt it through detailed notification3Develop a Category B herbal medicine or Category C health productSee the development pathway
VISBIO · laboratory in the TIBD group
Volatile compound analysis by GC-MS
Analytical testing of Lime Peel raw materials and products by VISBIO, the laboratory in our group.
See the VISBIO serviceK-API · manufacturing in the groupExtract and manufacture at K-API
The TIBD group plant licensed by the Thai FDA to manufacture herbal products, so extraction and production stay within the group.
See the K-API plantTIBD · consultationPlan a product with Lime Peel
We check whether your formula qualifies for notification, detailed notification or registration with the Thai FDA, then prepare the filing documents.
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